HUPO: The day of the research initiatives

HPP Day and π-HuB

Thursday, October 24, 2024 - 8:30-15:30

The Human Proteome Project (HPP), HUPO’s flagship project, has provided significant outcomes in mapping the entire human proteome in a systematic international effort such as the high-stringency draft of the human proteome, connections to biology and disease, and forging the understanding of every human protein’s function.
The HPP has delivered on our enhanced understanding of human biology at the cellular level and lay a foundation for development of diagnostic, prognostic, therapeutic, and preventive medical applications. The “HPP Grand Challenge” further explores the human proteome by understanding proteins in their network environment that will enable the elucidation of biological significance, and ultimately function of proteins. In combination with π-HuB, large scale efforts are already underway to dissect the functional states of the human proteome that are exemplified by PTMs, structural states, localization, and interactions and context-specific interdependencies of these attributes. During the diferent sessions, you will learn, and engage with scientists regarding the world-wide efforts in advancing the human proteome, its functions and its implication in health and disease.

Final agenda

8:30-9:30
HUPO, HPP, π-HuB Welcome and introduction

Welcome and introduction - Cecilia Lindskog & Fuchu He (10 min)
Overview of the Grand Challenge and reflections from 2023 - Charles Pineau (Inserm, Rennes, France) (15 min)
Functional proteomics in the π-Hub project - Fuchu He (NCPSB, China) (15 min)
Discussion (20 min)

9:30-10:30
Scientific session 1: Functional Diversity of Proteoforms

Microproteins and the non-canonical proteome in childhood cancer - Sebastian van Heesch (Utrecht, The Netherlands) (15 min)
Profiling Metalloproteomes by Chemical and Computational Proteomics - Chu Wang (Peking University, China) (15 min)
Proteomics tools facilitate the discovery of the new function of PTMs - Mingliang Ye (CAS, China) (15 min)
Discussion – 3 proposed questions for each speaker and each speaker provides a question (15 min)

10:30-11:30
Scientific session 2: Subcellular Proteome and PPI

Inferring protein function from proteomics data - Kathryn Lilley (Cambridge, UK) (15 min)
Bioorthogonal photocatalytic proximity labeling for spatiotemporal proteomics - Xinyuan Fan (Peking University, China) (15 min)
New technology for large-scale analysis of in situ conformation and interaction of proteins in live cells - Qun Zhao (CAS, China) (15 min)
Discussion – 3 proposed questions for each speaker and each speaker provides a question (15 min)

11:30-12:30
Scientific session 3: Computational Approaches to Protein Functions

Representing gene function using the Gene Ontology - Pascale Gaudet (SIB, Geneva) (15 min)
Neuro-symbolic AI reveals the functions of proteins in complex systems - Robert Hoehndorf (Thuwal, Saudi Arabia) (15 min)
Approaches to assigning functions to the unknome - Sean Munro (Cambridge, UK) (15 min)
Discussion – 3 proposed questions for each speaker and each speaker provides a question (15 min)

12:30-13:30 Lunch Break

13:30-14:30
ECR session: Innovative approaches to study protein function

(Presentations selected from submitted abstracts)

ECR short talk #1 (15 min)
ECR short talk #2 (15 min)
ECR short talk #3 (15 min)
Discussion round among the ECRs (15 min)

14:30-15:30
Discussion round all participants (50 min)

Wrap up Charles Pineau & Fuchu He (10 min)